FILAMENT-FILAMENT SWITCHING CAN BE REGULATED BY SEPARATION BETWEEN FILAMENTS TOGETHER WITH CARGO MOTOR NUMBER.

Filament-filament switching can be regulated by separation between filaments together with cargo motor number.

How intracellular transport controls the probability that cargos switch at intersections between filaments is not well understood.In one hypothesis some motors on the cargo attach to one filament while others attach to the intersecting filament, and the ensuing tug-of-war determines which filament is chosen.We investigate this hypothesis using 3D c

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Negative pressure wound therapy and split thickness skin graft aided in the healing of extensive perineum necrotizing fasciitis without faecal diversion: a case report

Abstract Background Perineum necrotizing fasciitis, also known as Fournier gangrene (FG), is a rare but highly mortal infectious necrotizing fasciitis with or without involvement of the underlying muscle.Evidence exists that negative pressure wound therapy (NPWT) combined with a split thickness skin graft (STSG) can help to heal wounds with FG.Howe

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Dimethyl Sulfoxide Inhibits Bile Acid Synthesis in Healthy Mice but Does Not Protect Mice from Bile-Acid-Induced Liver Damage

Bile acids serve a vital function in lipid digestion and absorption; however, their accumulation can precipitate liver damage.In our study, we probed the effects of dimethyl sulfoxide (DMSO) on bile acid synthesis and the ensuing liver damage in mice induced by bile acids.Our findings indicate that DMSO efficaciously curbs bile acid synthesis by in

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